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Each has its strengths and specific applications, and understanding these differences can inform more precise experimental design

In trials where semaglutide was added on to basal insulin with or without metformin, severe hypoglycemia (requiring the assistance of another person) was reported in 1.5% of semaglutide-treated patients

treatment often starts with an aggressive loading dose of 1000 mcg injections several times a week before tapering to monthly or bimonthly shots once levels stabilize