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Clinician Perspective The ADA Standards of Care 2024 state directly: "Routine supplementation with antioxidants, such as vitamins E and C and carotene, is not advised because of lack of evidence of efficacy and concern related to long-term safety." [6] Glutathione is not explicitly addressed in this language, but the guidance reflects a broader evidentiary standard the ADA applies to antioxidant supplements in diabetes management

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(2007) in the Journal of Cosmetic Dermatology tested 1% GHK-Cu cream twice daily for 12 weeks and demonstrated statistically significant increases in dermal collagen density

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Products with documented Certificates of Analysis (COA) often cost more but provide greater confidence in quality