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Membrane-bound phosphoinositide 3-kinase (PI3K) is the most common mediator of mTOR activation, forming the core of the PI3K/AKT/mTOR pathway along with AKT (45)

10.31083/j.rcm2502072 238 ZhangP.ZhuB.DuP.Travas-SejdicJ

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If the levels are chronically high, then there would be a reason to be concerned