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Alpha-lipoic acid: an inhibitor of secretory phospholipase A2 with anti-inflammatory activity

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The hypercoagulopathy in patients with thalassemia has been attributed to several risk factors including abnormal RBCs, chronically activated platelets, enhanced platelet aggregation, iron overload, splenectomy, and increased prothrombin generation 6,7,8,9

Verma, M

Gerriets VA, Danzaki K, Kishton RJ, Eisner W, Nichols AG, Saucillo DC, et al

Treated mice showed decreased susceptibility to muscle damage, improved muscle strength, reduced PARP activity, increased NAD + levels, and elevated mitochondrial function 254 , thus suggesting a potential therapeutic benefit of NR supplementation in DMD