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Pharmacologically mediated, marked initial maternal body weight loss and reductions in body weight gain and food consumption coincided with the occurrence of sporadic abnormalities (vertebra, sternebra, ribs) at greater than or equal to 0.075 mg/kg twice weekly (greater than or equal to 2 times human exposure)

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The photoaging studies used surrogate cosmetic endpoints skin density on ultrasound, wrinkle profilometry, investigator visual grading