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However, in the absence of TH, due to a different structural conformation in the unliganded state, the TRs recruit a co-repressor complex (Co-R) with histone deacetylase activity (HDAC) that induces a repressive chromatin environment to prevent transcription of target genes

181 Therefore, therapeutics that reduce signaling through these receptors to facilitate high-quality sleep are being developed

Particularly those who spend hours in air-conditioned settings, whose muscular rigidity is weakened

W., Coll, A

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