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2 Molecular mechanisms of ferroptosis Ferroptosis, a novel form of cell death distinct from apoptosis, pyroptosis and autophagy, is an iron-dependent programmed form of cell death characterized by an iron metabolism disorder, imbalance of the redox system and the accumulation of lipid peroxides ( Ferroptosis is an evolutionarily conserved process that occurs in mammals and various organisms (such as plants and microorganisms)

Involvement of oxidative stress The increase in reactive oxygen species (ROS) caused by smoking is thought to play a critical role in vascular endothelial dysfunction

AMPK, as a central regulator of energy homeostasis, has been widely investigated in diverse human diseases and is considered a promising interference target in DKD

SURPASS-1 shows that tirzepatide alone, at all doses, was superior to placebo and revealed a dose-dependent reduction of HbA1c by up to 2.07% (p 10% weight loss can be disease modifying and may even lead to disease remission [38]

8a could also explain the previously observed sequential kinetic patterns for the small non-glutathione substrate HEDS (Fig

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