maritide glp-1 Trial Scorecard: Once-Monthly MariTide Shows Promise for

10.1177/1933719115612133 22 HarrisM

Is Dialysis a Prohibited Method

Journal of Biological Chemistry, 286(24), 2176721778

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Despite the myriad of ASMs available, 1/3 of the patients are considered drug-resistant or refractory (intractable epilepsy) (4, 5)

Experience employing dosing regimens from once-a-day to four-times-a-day, as well as studies in primate epilepsy models involving constant rate infusion, indicate that total daily systemic bioavailability (extent of absorption) is the primary determinant of seizure control and that differences in the ratios of plasma peak to trough concentrations between valproate formulations are inconsequential from a practical clinical standpoint