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L-NAME rats exhibited the moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc, faint presentation of the choroidal blood vessels appearing immediately, and these lesions (Figure 2, IN, IIN), and a rapid progress to the severe stage (Figure 3, AC

Studies have shown that significant concentrations of lixisenatide were found in the brain of mice 30 minutes and 3 hours after intraperitoneal injection, suggesting that lixisenatide could cross the BBB (125)

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Best Pract Res Clin Endocrinol Metab 24(5):763773