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Finally, in the second phase, polymorphisms on ALDH2 (Aldehyde Dehydrogenase 2 Family (mitochondrial)) can result in an inactive ALDH enzyme and a high risk of acetaldehyde toxicity after consumption of alcohol or smoking

However, there is no evidence for this hypothesis

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As we age, or during periods of stress or illness, NAD levels can decline, impacting recovery, energy, and overall wellness