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These two peptides stimulate growth hormone release through two independent receptor pathways : CJC-1295 activates GHRH receptors the same pathway used by your body's natural growth hormone-releasing hormone Ipamorelin activates ghrelin receptors (GHS-R) an entirely separate signaling pathway on the pituitary Stimulating both pathways simultaneously produces a synergistic growth hormone response the combined GH output is significantly greater than the sum of each peptide individually

Regardless of mechanism, clinical observations support a nausea-reducing effect in a subset of users

Biomechanical testing showed treated ligaments achieved 78% of pre-injury tensile strength by day 14 versus 42% in controls

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But they work differently, and the differences matter when funding an ongoing treatment protocol