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Produced during periods of inflammation and oxidative stress, prostaglandin F 2 (PGF 2 ) is an eicosanoid, which promotes the formation of 8-iso-PGF 2 and 2,3-dinor-5,6-dihydro-8iso PGF 2 (Reference Basu69,Reference van t Erve, Lih and Kadiiska70)

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The formulation of N 4-hydroxy metabolite is mediated viaCYP2C9

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