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Treatment depends on the cause and severity: dietary deficiency may be treated with oral B12 supplements, while pernicious anaemia or neurological symptoms typically require intramuscular hydroxocobalamin injections

ONE STRENGTH FOR ALL DOG SIZES Give a full 1000 mg tablet for large breeds or adjust in 250 mg increments for smaller dogs and sensitive or aging pets

Ethics declarations Acknowledgements Medical writing support in the preparation of this manuscript was provided by Susie Eaton, MBio, and Tom Priddle, DPhil, of OPEN Health Communications (UK), funded by Boehringer Ingelheim

The primary concerns are cardiovascular strain (increased heart rate/blood pressure) and severe dehydration/malnutrition due to the combined effect of both drugs on your central nervous system and gut.

As with any form of medical treatment, it is crucial to consult with a healthcare professional before attempting nebulization

doi: 10.1074/jbc.273.37.23625 44 CelesteD