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[4] [7] Berberine should also be avoided during pregnancy and breastfeeding

The reductions in GAA provide better control of the refractory epilepsy that is common in GAMT deficiency

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In a randomized, double-blind, placebo-controlled pilot trial published in Movement Disorders (2009) by Hauser and colleagues (21 patients), intravenous glutathione at 1,400 mg three times weekly was well tolerated with no withdrawals due to adverse events, although it did not produce statistically significant efficacy differences versus placebo