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You should contact your GP or NHS 111 if you experience: Persistent diarrhoea lasting more than 7 days in otherwise healthy adults Blood or mucus in stools , which may indicate inflammatory bowel disease or infection Severe abdominal pain or cramping that is worsening or different from previous digestive symptoms Unexplained weight loss alongside bowel changes Signs of allergic reaction , including rash, itching, swelling, or difficulty breathing (call 999 or go to A&E for severe reactions) Neurological symptoms such as numbness, tingling, balance problems, or memory difficulties, which may indicate B12 deficiency is not being adequately treated Seek help sooner if you have red flag symptoms, are pregnant, immunosuppressed, elderly, or have significant underlying health conditions

It helps nerves send signals. Who Needs B12 Supplementation Some groups are more likely to need B12 supplements

Prolotherapy: Injection of dextrose or other irritant solutions triggering inflammation and healing response

Tesofensine (500mcg) is a weight loss compound that works by blocking the reuptake of dopamine, serotonin, and norepinephrine, helping to suppress appetite and reduce food cravings

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These decisions will play a critical role in determining whether peptide therapies move closer to mainstream clinical use or remain in a more limited regulatory position