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Animal studies have demonstrated anti-inflammatory effects of GLP-1 receptor agonists in models where weight loss was minimal or absent, suggesting direct pharmacological actions on inflammatory pathways

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Measuring the activities of energy-metabolizing enzymes The activity of the rate-limiting glycolytic enzyme, hexokinase was measured using the Hexokinase assay kit (Sigma-Aldrich Fine Chemicals, St Louis, MO, United States) as per the manufacturers protocol

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[DOI] [PubMed] [Google Scholar] Casas R, Muthusamy S, Wakim PG, Sinharay S, Lentz MR, Reid WC, Hammoud DA (2017) MR brain volumetric measurements are predictive of neurobehavioral impairment in the HIV-1 transgenic rat