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02.Clinical Significance: Metabolic disorders during the recovery phase of myocardial infarction can weaken the body's resistance and slow the recovery process

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[DOI] [PubMed] [PMC] Komatsu M, Kanda T, Urai H, Kurokochi A, Kitahama R, Shigaki S, et al

Published preclinical work has described: Reduced de novo lipogenesis in adipocytes Reduced hepatic lipogenesis in diet-induced obesity models Improved adipose tissue metabolic markers Licensed Healthcare Practitioners 1,000+ physician-grade products, bulk-tier pricing, and direct shipping to your practice

The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough