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Reszta histydyny w pozycji rodkowej nadaje czsteczce charakterystyczne miejsce koordynacji metalu, a obecno lizyny adunek dodatni sprzyjajcy interakcjom z ujemnie naadowanymi skadnikami macierzy (glikozaminoglikany, proteoglikany)

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The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study randomized approximately 5,000 patients with relatively recent onset of T2DM (4.2 years) on metformin therapy to sulfonylureas, DPP-4 inhibitors, GLP-1 RAs, or insulin (16)

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Agarwal R, Rossing P, Mann JFE