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NNMTi-mediated changes to the availability of nicotinamide/nicotinic acid in conjunction with the presence of moderate amounts of Lactobacillus may promote a positive feedback loop further increasing the abundance of Lactobacillus

& Rao, P

(5) Research has shown that by preserving nicotinamide from NNMT-mediated degradation, the compound may enhance NAD+ synthesis through the salvage pathway

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arXiv preprint arXiv:math/0603291