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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 30% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

For broader pharmacokinetic context, see Peptide Half-Life Explained: Why Some Peptides Last Hours and Others Days

Much has been made of molecular mimicrythat is, the molecular similarity between a viral component for instance and an endogenous CNS protein leading to mistargeted autoimmunityin the pathogenesis of MS (Lang et al., 2002

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In recent years, it has been found that mitochondria are a key component of the bone tissue and that mitochondria-derived peptides play a role in bone metabolism, in addition to their role in regulating metabolic homeostasis (Lee et al., 2015