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Semaglutide is a prescription medication with an FDA boxed warning

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3.4 SURMOUNT1 Trial SURMOUNT-1 trial was a randomized, double-blind, placebo-controlled phase 3 trial evaluating the safety and efficacy of tirzepatide in 2539 obese (BMI 30) or overweight (BMI 27) adult patients with at least one weight-related comorbidity, excluding diabetes

It appears to work in part by promoting angiogenesis, the formation of new blood vessels, which accelerates delivery of repair signals to damaged tissue

Stokes, J

Trulicity is not insulin and can be prescribed alongside insulin, metformin, or sulfonylureas