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The only two absolute reasons why a person cannot be considered for semaglutide are either a personal or family history of medullary (C-cell) thyroid cancer or multiple endocrine neoplasia type-2

Activation of dopamine D2 receptor promotes pepsinogen secretion by suppressing somatostatin release from the mouse gastric mucosa

Research shows that semaglutide may help lower systolic blood pressure, especially in people with obesity, insulin resistance, metabolic syndrome, or type 2 diabetes

This Can Sometimes Lead to Gastrointestinal Adverse Events, Including Changes in Bowel Habits and Discomfort

Continue to use semaglutide injection even if you feel well

The key takeaway here is that as long as the medication is administered correctly, either site should work well for weight loss or diabetes management