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Value-based healthcare models increasingly recognize the importance of clinical outcomes rather than simply drug acquisition costs

Alternatively, they may be deficient in B12 for other reasons

The short dihexa half life does not limit therapeutic duration

Amount of body fat - Body fat does not absorb alcohol, so alcohol is more concentrated in anyone with a high proportion of body fat

Even at doses far exceeding the standard 10 mcg/kg range (scaled to human-equivalent doses of roughly 200-800 mcg/day for a 70-kg adult), researchers have not observed pathological angiogenesis, tumorigenic signaling, or behavioral toxicity 1

PMID: 36223440