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Vitamin B12, or methylcobalamin, is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis

Not a trivial amount

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American Association of Clinical Endocrinologists and American College of Endocrinology: clinical practice guidelines for developing a diabetes mellitus comprehensive care plan 2015

It is the leading cause of nephropathy and end-stage kidney disease, neuropathy, retinopathy and adult-onset blindness, non-traumatic amputation, and contributes greatly to heart disease and cardiovascular morbidity and mortality ( This meta-analysis showed that when initiated at the prediabetic stage, interventions with medications, specifically SGLT-2 inhibitors and GLP-1 receptor agonists, show promising evidence in delaying the progression of prediabetes into diabetes

It is the cleavage product of GLP-1 (1-36) amide peptide