Second, the rules shifted recently: after the FDA declared the semaglutide shortage resolved in early 2025, the special allowances that let pharmacies widely compound semaglutide were phased out over that year
Directions may differ by brand or formulation
How Semaglutide Might Affect Thyroid Function TSH, T3, and T4 Changes Some semaglutide users experience changes in thyroid-stimulating hormone (TSH) levels, particularly during active weight loss
RX are up to a medical providers discretion
Concurrent medications may affect muscle metabolism
These numbers are unprecedented for a non-surgical, pharmacological intervention and notably the weight-loss curve had not fully plateaued at 48 weeks, suggesting that even greater reductions might occur with longer exposure