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Physiological reviews, 89(4), 13791412

184,185 The pathophysiology of DRPN involves ischemic injury due to microvasculitis leading to nerve fiber ischemia and immune-mediated mechanisms, as evidenced by inflammatory infiltrates in nerve biopsies

Is a 10 day protocol 1x/year

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During this process, myofibroblasts irreversibly form, followed by the production of multiple types of collagens and accumulation of extracellular matrix, eventually resulting in renal tubulointerstitial fibrosis

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