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Downregulation of Sirt3 contributes to -cell dedifferentiation via FoxO1 in type 2 diabetic mellitus
J.CogganM.LittlerD
It is involved in a variety of biological processes, including epigenetic regulation, post-translational modification of proteins and metabolism
Their germline phenotypes were analyzed by staining dissected gonads with cell fate-specific markers: anti-REC-8 (Hansen et al., 2004b) and anti-HIM-3 (Zetka et al., 1999) antibodies
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Specifically, colistin significantly promotes the upregulation of HDAC1 expression and leads to the deacetylation of histone 3 lysine 27 (H3K27) in the Nrf2 (the master regulator of anti-oxidant response) promoter region to inhibit the activity of the Nrf2 signaling pathway
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