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GHK-Cu is a peptide that would be broken down by digestive enzymes if taken orally

In these cases, they should stop taking semaglutide and contact their healthcare provider immediately or call NHS 111 for advice

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Patients should: Follow the dose escalation schedule to minimise side effects Attend regular follow-up appointments to monitor progress and safety Engage with dietetic support to ensure adequate nutrition whilst reducing calorie intake Combine medication with increased physical activity (aim for 150 minutes moderate-intensity exercise weekly, plus muscle-strengthening activities on at least 2 days per week, as per UK Chief Medical Officers' guidelines) Structured lifestyle programmes : NICE recommends multicomponent interventions including dietary modification, physical activity, and behavioural strategies

Wegovy may be used with other medications, but combining treatments can increase certain risks

Am J Kidney Dis 71(1):6574 Tonneijck L, Muskiet MHA, Smits MM, van Bommel EJ, Heerspink HJL, van Raalte DH et al (2017) Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment