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These numbers mean that approximately 82 to 88% of participants completed the trial without dropping out due to side effects, even at the highest doses

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The absence of a standard regimen does not mean the decision is flexible or casual

doi: 10.3389/fphar.2021.724439 Received 13 June 2021 Accepted 14 December 2021 Published 24 January 2022 Volume 12 - 2021 Edited by Ashwell Rungano Ndhlala, University of Limpopo, South Africa Reviewed by Muhammad Nadeem, University of Veterinary and Animal Sciences, Pakistan Bin Zeng, South China Agricultural University, China Updates Copyright 2022 Alia, Putri, Anggraeni and Syamsunarno

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This protective effect of riboflavin could be attributed to dihydroriboflavin, produced by the flavin reductase activity of NADPH-dependent methaemoglobin reductase ( Reference Hultquist, Xu and Quandt 57 )