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Since these cells are the most resistant cells to chemotherapy and radiotherapy within the tumor [17], they are considered as responsible for tumor relapse [15]
This connection existed in both children and adults
doi: 10.3233/JAD-2005-7107 55 McNayECOngCTMcCrimmonRJCresswellJBoganJSSherwinRS
To elucidate the contribution of gpoA in the H 2 O 2 detoxification system of S
Therapeutically, these cells can be further potentiated using agents that intensify iron release (e.g., NCOA4 activators), enhance ACSL4-mediated PUFA incorporation, or inhibit GPX4-stabilizing pathways ( Collectively, these strategies demonstrate that metabolically targeting TAM subsets is a powerful approach to controlling ferroptosis, suggesting multiple avenues for combination therapies that integrate ferroptosis inducers, immune checkpoint modulators, and metabolic inhibitors