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The conversion of glutamine into glutamate is regulated by an oxidative reaction orchestrated by glutaminase (Zhang et al., 2022b)
However, this process may be limited as PDC activity is significantly reduced in the presence of excess acetyl groups
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In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials
Some patients report that evening administration may help them sleep through initial nausea, though evidence for specific timing recommendations is limited and individual responses vary considerably
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