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This principle, sometimes described as "receptor promiscuity" in the GPCR field, has profound implications for drug design, suggesting that active receptor conformations represent energetically favorable states that can be accessed through diverse molecular triggers

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If symptoms last more than 7 days, consult a doctor

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For the first time, a major global health authority is formally acknowledging that obesity is a chronic, biologically driven disease not a matter of willpower and that effective medical therapy has an important role

This does not invalidate the results they were published in the most rigorous peer-reviewed journal in medicine but it is standard practice to disclose