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Public dataset and bioinformatics The GEO datasets were downloaded from NCBI (www.ncbi.nlm.nih.gov)

79 In diabetes, the sugar metabolite methylglyoxal could be responsible for increased oxidative stress, synthesis of AGE product with a simultaneous enhancement of inflammation, and a decline in NO (nitric oxide) availability in the endothelium

Annular scaly lesions or psoriasiform lesions in a photo-distribution are a hallmark

Ravikumar V, Ahmed A, Anjankar A

Characterized by insulin resistance, gradual progressive loss of insulin secretion by -cells, and being heavily driven by being overweight or obese [98], T2DM leads to hyperglycemia, excessive urine production, increased risk of cardiovascular disease, and changes in energy metabolism [106]

Photographic Documentation Protocol Not required unless injection site reaction occurs