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Since peptides are, by definition, short chains of amino acids, they are vulnerable to this digestive onslaught

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Also, TGR5 seems to have an important role in the maintenance of intestinal barrier integrity, since murine models TGR5 deficient developed an increased intestinal permeability, made of an altered molecular architecture of epithelial thigh junctions with an increased expression and an abnormal distribution of zonulin-1 [25]

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Many studies indicate an association between increased VEGF expression in the brain, brain hypoperfusion, and increased BBB permeability, which increases unwanted angiogenesis, and may favor the occurrence of neurodegenerative diseases (Chen et al