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Modifier 25 is appended to the E/M code (not 12020) when a separately identifiable evaluation and management service occurs on the same date

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139 CDC42, a master regulator of epithelial cell polarity, is activated by TUBA, an apically localized guanine nucleotide exchange factor (GEF) for CDC42, and positively regulates the activity of aPKC to promote apical membrane identity and the formation of adherens junctions, and to control vesicle trafficking 6,119,129,140,141 (Figure 3(a))