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Management of sicca syndrome [5] [9] Xerostomia All patients Frequent water intake Caries prophylaxis, e.g., regular dental hygienist visits, topical fluoride or chlorhexidine Avoidance of irritants (e.g., coffee, alcohol) and acidic beverages (e.g., herbal tea, cola) [10] Artificial saliva Preferred treatment for patients without residual glandular function May be considered for all patients Patient with residual glandular function: stimulation of salivary flow First line: nonpharmacological stimulants, e.g., sugar-free lozenges or gum, acidic candy, xylitol Second line: oral muscarinic agonists Usually reserved for moderate or severe salivary dysfunction because of their potential adverse effects and the lack of strong evidence supporting their benefit Options: pilocarpine, cevimeline Muscarinic agonists are contraindicated in patients with asthma, multiple sclerosis, and/or glaucoma

Additionally, these agents help regulate postprandial glucose by suppressing hepatic glucose production and delaying gastric emptying

With the Boards of Appeal revoking several Novo Nordisk patents relating to the active ingredient semaglutide in recent months, this represents a success for the patent holder

Poder abordar la obesidad con una pastilla de GLP-1 es un avance significativo en el manejo del peso

When your body gets used to eating less and losing fat, your brain can see changes in things like serotonin, which helps control mood

That can be hard for people who have never done it before