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The first involves the interaction between one molecule of H 2 O 2 and CAT which leads to the production of Compound I, in which the heme group is oxidized to oxyferryl species [45, 50, 52]

POWERFUL ANTIOXIDANT DEFENSE: Glutathione is an extremely important cell protectant

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

These ROS then attack phospholipids rich in polyunsaturated fatty acids (PUFAs) on cell membranes, leading to the accumulation of lipid peroxides (LPOs) and compromising membrane integrity ( Figure 1 )

N Ballatori, SM Krance, S Notenboom, S Shi, K Tieu, CL Hammond

[DOI] [PubMed] [Google Scholar] 79.Steinert JR, Chernova T, Forsythe ID