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While some studies show little or no increased risk, the findings have been significant enough to draw regulatory attention

95% CI [0.991.185]

Potential impact on food preferences: Some studies and patient reports suggest that GLP-1 medications like Rybelsus may decrease cravings for high-fat, sugary, or processed foods

Subsequently, KCs initiate the production of TNF-a and IL-6, and secreted TNF-a can bind to TNF receptor 1 (TNF-R1) and amplify this reaction in an autocrine manner

doi: 10.1056/NEJMoa2025845 210 LattenistLLechnerSMMessaoudiSLe MercierAEl MoghrabiSPrinceSet al