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50 Less than 10% of patients with distant metastases survive after 5 years

Gradualmente, se ha activado la complementacin con carnitina y poco a poco ha despertado el inters de la comunidad cientfica

However, the currently available data remain very limited, based on small cohorts and not derived from prospective randomized controlled trials

If Vitamin B12 deficiency is ignored: It can lead to permanent nerve damage May result in mental confusion or dementia Muscles may weaken over time It can increase heart-related risks The problem usually starts slowly and is often ignored until it becomes serious

About the EMPA-REG OUTCOME Trial (NCT01131676) EMPA-REG OUTCOME was a long-term, multicenter, randomized, double-blind, placebo-controlled trial of more than 7,000 patients, from 42 countries, with type 2 diabetes and established cardiovascular disease

Selective serotonin reuptake inhibitors (SSRIs) : Antidepressants such as fluoxetine or sertraline may help reduce binge frequency, particularly when depression or anxiety co-exists, though they are used off-licence for this indication