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Figure 3 shows the mRNA and protein expression of genes GCLC (glutamate-cystein ligase catalytic subunit)/ GCLM (glutamate-cysteine ligase regulatory subunit)/ GSS/NRF2 (nuclear factor erythroid-2-related factor) involved in GSH synthesis (Fig

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The presence of DHODH in mitochondria and its capacity to neutralize lipid peroxides support its protective role against ferroptosis, while DHODH deficiency has been demonstrated to induce ferroptosis [71]