Vitamin B12 deficiency is a common issue in India, affecting around 50% of the population
National Heart, Lung, and Blood Institute, et al
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Mitochondrial disease is diagnosed by using an integrated approach with multiple means and a detailed history, which would include: Brain imaging Clinical observations Evaluating laboratory results Muscle biopsies An alert physician with experience in orthomolecular medicine is usually required for a proper diagnosis as it is rare that genetic testing would be adequate for an accurate diagnosis of the disease
However, under oxidative stress, oxidative modification of cysteine residues in Keap1 causes conformational changes that weaken its binding to Nrf2, allowing Nrf2 to dissociate from Keap-1 and rapidly translocate to the nucleus
Only the reduced form has an antioxidant effect and contributes free radical scavenging and anti-inflammation