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These biomarkers related to chronic oxidative stress and inflammation were significantly abnormal at baseline in the BH4 treatment participants as compared to those who received placebo

Additionally, synovitis is a key factor in the development of KOA

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Phytomedicine 18(23):134142 Lee SY, Lee KS, Yi SH, Kook SH, Lee JC (2013) Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production