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Therefore, BIRD domain inactivation or deletion could constitutively activate transcription of purine pathway genes and synthesize an excess of GTP, which must be detoxified via riboflavin overproduction

This coordinated activation allows calcium to flow into the neuron, a fundamental process that drives synaptic plasticity, long-term potentiation, learning, and memory formation

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Sitohang is with the Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr

Most studied potential mechanisms include neuroplasticity effect, oxidative stress and neurotransmitter regulation