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Analogs such as 6-diazo-5-oxo-l-norleucine (DON) and acivicin did show cytotoxic effects against several tumor types, including leukemia and colorectal cancers

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Excessive protein glutathionylation was shown to be associated with various diseases, including tumorigenesis [91], antitumor drug resistance [92], cardiovascular diseases [93], and neurodegenerative diseases [94,95], which is to be discussed in the following sections within this review