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Glycine as a collagen precursor in pulmonary fibrosis Glycine, which constitutes approximately one-third of the amino acids in collagen, plays a pivotal role in ECM accumulation during pulmonary fibrosis [17]

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In mouse models, dual agonism had superior efficacy for weight loss and glucose control compared to a GLP-1RA alone 9 , with additive effects of the GIPR proposed to act through signaling in beta cells 10 , alpha cells 11 , the CNS (central nervous system) 12,13 and adipocytes 14