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The authors of the 2020 study noted liraglutide is a daily subcutaneous injection, whereas semaglutide is weekly, which may have impacted adherence to liraglutide

Sleep disturbance for some people While many sleep through side effects, others may feel restless or alert

Nat Med 31 , 28652866 (2025)

Here are some common pitfalls to avoid: Neglecting to Refrigerate After Opening: Some users may forget that compounded semaglutide should be refrigerated after the first use, which can compromise its effectiveness

Safety assessments included treatment-emergent adverse events, serious adverse events and changes in vital signs and laboratory assessments according to the protocol

[10] [11] Additional safety considerations include caution in patients with severe gastroparesis, gallbladder disease, and a potential risk of diabetic retinopathy complications with rapid glucose improvement (particularly with semaglutide)