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It might have been a little bit worse than usual, just because it is a pretty high dose

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Therefore, drug delivery targeting the extracellular region of target receptors faces several insurmountable challenges, including (1) competitive interference from endogenous ligands or antibodies at the target and (2) pseudotarget or target loss caused by shedding or mutation of the extracellular region, which significantly inhibits drug efficacy and may pose safety concerns

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Reuters This article originally appeared on USA TODAY: Foundayo joins Wegovy as GLP-1 pill option