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Author: Emily Adamek (Change) Medical Reviewer: Kristen Fuller, MD (No change) Primary Changes: Fact-checked and edited for readability

For someone starting at 250 pounds, for example, this could mean the difference between losing 37 pounds with Semaglutide and 50 pounds with Tirzepatide

GLP-1 is a gut hormone released after eating that signals the brain to reduce appetite, slows gastric emptying (so you feel fuller longer), stimulates insulin release from the pancreas, and suppresses glucagon (which would otherwise raise blood sugar)

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