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In this study, 17 out of 21 patients receiving fecal microbiota transplantation from ten different donors achieved at least a 60% improvement [161]

That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route

These nootropics are typically prescribed by healthcare professionals and are subject to rigorous testing and regulation that reduces possibility of health risks, but they may come with side effects

The effect was more pronounced with microgram doses of NaBPC157

When combined with appropriate testosterone optimization, IGF-1 can amplify the benefits of both therapies

And it is pretty rewarding to get those folks to transition and see the value in it