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Thus, integrins are conduits that convert signals from the ECM environment (rigidity, elasticity and topology) into intracellular biochemical signals that affect cytoskeleton organization, gene expression, and proliferation ( The specificity and activation of each integrin can occur within subseconds and is therefore likely to be highly regulated by the spatiotemporal expression and activation of other integrins and receptors on the cell surface ( At least two integrins found in the TM/SC are known to have a tunable conformation and thus their activity is likely to be altered depending upon the composition and 3D architecture of the ECM in the TM/SC

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